The aggregate gross proceeds to Xenon from the offering, before deducting underwriting discounts and commissions and other offering expenses payable by Xenon, were approximately $287.5 million. Our Products, Our Products to give best care for your eyes. The decrease of $13.7 million was attributable to deferred revenue related to the transfer of exclusive licenses and associated technology and know-how for certain compounds under the license and collaboration agreement with Neurocrine Biosciences being fully recognized by December 2020, partially offset by recognition of $5.3 million of milestone revenue in connection with the license and collaboration agreement with Neurocrine Biosciences, $3.0 million of milestone revenue in connection with the agreement with Pacira BioSciences and an increase in research and development services revenue. To participate in the call, please dial (855) 779-9075, or (631) 485-4866 for international callers, and provide conference ID number 7079889. These forward-looking statements are not based on historical fact, and include statements regarding the timing of and results from clinical trials and pre-clinical development activities, including those related to XEN496, XEN1101, and other proprietary products, and those related to NBI-921352, PCRX301, and other partnered product candidates; the potential efficacy, safety profile, future development plans, addressable market, regulatory success and commercial potential of XEN496, XEN1101 and other proprietary and partnered product candidates; the anticipated timing of IND, or IND-equivalent, submissions and the initiation of future clinical trials for XEN496, XEN1101, and other proprietary products, and those related to NBI-921352, PCRX301, and other partnered candidates; the efficacy of our clinical trial designs; our ability to successfully develop and achieve milestones in the XEN496, XEN1101, and other proprietary development programs; the timing and results of our interactions with regulators; anticipated enrollment in our clinical trials and the timing thereof; the progress and potential of our other ongoing development programs; the potential receipt of milestone payments and royalties from our collaborators; our expectation of having sufficient cash to fund operations into at least 2024; our efforts to enhance our intellectual property portfolio; the timing of potential publication or presentation of future clinical data; and the sale of any common shares pursuant to the at-the-market equity offering, including the price, volume and timing of any distributions. Research and development expenses for the year ended December 31, 2021 were $75.5 million, compared to $50.5 million for the same period in 2020. Xenon will host a conference call and live audio webcast today at 4:30 pm Eastern Time (1:30 pm Pacific Time) to discuss the year-end results and to provide a corporate update. Xenon Pharmaceuticals Financials Summary financials Revenue ( Q2, 2022) $536.0K Gross profit ( Q2, 2022) $536.0K Net income ( Q2, 2022) ($31.2M) Cash ( Q2, 2022) $370.0M EBIT ( Q2, 2022) ($31.6M) Enterprise value $1.7B Competitors and similar companies China Medical System Healthcare - Public ReCept Pharmacy Healthcare - Private ELC Group The topline data showed all primary and secondary seizure reduction endpoints were statistically significant across all dose groups, including the primary endpoint of median reduction from baseline in monthly seizure frequency and in the key secondary endpoint of patients with at least a 50% reduction in monthly focal seizure frequency from baseline, with p-values of <0.001 for both the 20 mg and 25 mg dose groups. Xenon Pharmaceuticals (NASDAQ:XENE) is a clinical stage biopharmaceutical company committed to developing innovative therapeutics to improve the lives of patients with neurological disorders. Other income for the year ended December 31, 2021 was $0.1 million compared to $2.2 million for the same period in 2020. Xenon Pharmaceuticals Provides Updates on Proprietary Neurology Pipeline Programs at theAnnual Meeting of the American Epilepsy Society (AES 2022), Xenon Pharmaceuticals to Present at the Bank of America Securities Biotech SMID Cap Conference 2022, Xenon Pharmaceuticals to Participate in Upcoming Investor Conferences. Xenon anticipates participating in an end-of-Phase 2 meeting with the U.S. Food and Drug Administration (FDA) in the second quarter of this year to support the initiation of its Phase 3 XEN1101 clinical program in adult patients with focal epilepsy, estimated in the second half of the year. Funding Xenon Pharmaceuticals has raised a total of $942.6M in funding over 12 rounds. Xenon Pharmaceuticals Is An Ethical Pharma Company. Our novel product pipeline of neurology therapies addresses areas of high unmet medical need, with a focus on epilepsy. Importantly, two additional U.S. patents were granted in 2021 with claims related to: (1) compositions-of-matter covering four distinct crystalline forms of XEN1101 drug substance (including the forms used in current and future clinical development); and (2) methods of enhancing the bioavailability of XEN1101 by administration with or close to a meal (consistent with the dosing of XEN1101 in clinical studies). 54 (19.6%) and 26 (9.5%) of subjects in the OLE experienced a 6 and a 12 consecutive months of seizure freedom, respectively. For more information, please visit www.xenon-pharma.com. (Common Stock) Data Provided by Refinitiv. Monopoly working rights in your selected towns. Helping To Maintain Vision, Hearing Ability And Healthy Breathing Is The Noblest And Most Satisfying Activity That Is Beyond Commercial Interests. Mr. Ian Mortimer, Xenons President and Chief Executive Officer stated, We made significant progress in 2021, marked by the positive read-out of strong efficacy data from our XEN1101 Phase 2b X-TOLE clinical trial, which represented a transformative event for Xenon. In addition, Xenon is collaborating with the Icahn School of Medicine at Mount Sinai to conduct an investigator-sponsored Phase 2 proof-of-concept, multi-site, randomized, parallel-arm, placebo-controlled clinical trial of XEN1101 for the treatment of MDD, with patient enrollment underway. The offering was made only by means of a written prospectus and prospectus supplement that form a part of the registration statement. X-TOLE2 is expected to be initiated in the second half of 2022 followed by the initiation of X-TOLE3 and both studies will run in parallel. Pursuant to the terms of the agreement, Xenon has the potential to receive certain clinical, regulatory, and commercial milestone payments, as well as future sales royalties. The change was primarily attributable to higher research and development and general and administrative expenses, and lower revenue as compared to the same period in 2020. 2nd Floor J Block Vikaspuri Market. Weight changes in the OLE were 1.4 4.5 kg at the 6-month visit and 0.9 6.2 kg at the 12-month visit. Our novel product pipeline of neurology therapies addresses areas of high unmet medical need, with a focus on epilepsy. Xenon Pharmaceuticals Inc. (Nasdaq:XENE), a neurology-focused biopharmaceutical company, today announced that management will participate in one-on-one investor meetings and a fireside chat presentation at the Bank of America Securities Biotech SMID Cap Conference 2022 taking place virtually from December 7-8, 2022. At Week 1, the median percent reduction in monthly focal onset seizure frequency was 55.4% in the 25 mg group (p<0.001), 41.5% in the 20 mg group (p=0.039), and 39.1% in the 10 mg group (p=0.002) compared to 20.2% in the placebo group. Media/Investor Contacts:Jodi RegtsXenon Pharmaceuticals Inc.Phone: 604-484-3353Email:investors@xenon-pharma.com, Brazil economy ministry rejects Lula transition team's judgment on finances, Stock Markets Defining Moment Arrives With CPI, Fed Decision, Investor group launches campaign to help companies protect nature, Jamie Dimon Says Its Good Both Parties Wing Nuts Werent Elected, Inflation data, Fed meeting will set the table for 2023: What to know this week. We are Olema Oncology. A Phase 3 randomized, double-blind, placebo-controlled, parallel group, multicenter clinical trial, called the EPIK study, is underway to evaluate the efficacy, safety, and tolerability of XEN496 administered as adjunctive treatment in approximately 40 pediatric patients aged one month to less than six years with KCNQ2-DEE. Seizures are generally described in two major groups: generalized seizures and focal seizures. The outcome of the EOP2 meeting supports the advancement of XEN1101 into Phase 3 clinical development, and Xenon remains on track to initiate the Phase 3 program in the second half of 2022. Early treatment typically begins with monotherapy followed by increasing use of polypharmacy to manage patients with residual seizure burden. The many universities in the area give the region a large network of scientists. Xenon Pharmaceuticals Inc. Conference Call at 4:30 pm ET Today. We are a clinical stage biopharmaceutical company committed to developing innovative therapeutics to improve the lives of patients with neurological disorders. This analysis uses the denominator of all patients transitioning to the OLE (N=275) even though not all patients have been in the study long enough to be treated for at least 12 months. Our XEN1101-related presentations have been posted here. BURNABY, British Columbia, March 01, 2022 (GLOBE NEWSWIRE) -- Xenon Pharmaceuticals Inc. (Nasdaq:XENE), a neurology-focused . Land Line No. First Time in India Xenon Pharmaceuticals ISO Certified PCD Pharma Company in Hissar, Which is Provide All Over India, Eye drops Franchise service provide, For Franchise Contact Us. Burnaby, British Columbia, Canada 101-250 Post-IPO Equity Public www.xenon-pharma.com 9,877 Highlights Stock Symbol NASDAQ:XENE Total Funding Amount $942.6M Contacts 86 Employee Profiles 6 Investors 10 Similar Companies 69 - Mr. C. M. Joshi (Prop.) Home; Xenon anticipates that the EPIK study will be completed in the first half of 2023. Xenon plans to submit an NDA upon completion of the first XEN1101 Phase 3 clinical trial X-TOLE2, if successful, and use the existing data package from the Phase 2b X-TOLE clinical trial along with additional safety data from other clinical trials to meet regulatory requirements. "Xenon" and the Xenon logo are trademarks of Xenon Pharmaceuticals Inc. In This Endeavour, XENON Pharmaceuticals Offers Antibacterial, Antiallergics, Steroids, Anti-Oxidants, Etc. The products within our novel proprietary pipeline - including clinical-stage candidates XEN496 and XEN1101 - are aimed at treating neurological disorders, with a particular focus on epilepsy. Our partnered programs also continue to advance through development with two separate Phase 2 clinical trials underway from Neurocrine Biosciences in adult patients with focal-onset seizures and pediatric patients with SCN8A-related epilepsy.. Based on the strength of data from this time course to efficacy analysis, a key secondary endpoint in the Phase 3 trials will include the median percent change of weekly FOS at Week 1. Based on current assumptions, which include fully supporting the planned XEN1101 clinical development program, XEN496, and pre-clinical and discovery programs, Xenon anticipates having sufficient cash to fund operations into at least 2024, excluding any revenue generated from existing partnerships or potential new partnering arrangements. We are developing XEN1101, a differentiated Kv7 potassium channel opener, for the treatment of epilepsy, major depressive disorder (MDD), and potentially other neurological disorders. Burnaby, BC V5G 4W8, Tel: 604.484.3300 Despite the availability of multiple treatment options, approximately 50% of patients are considered inadequately managed with initial lines of therapy warranting additional treatment options. Our U.S. Company (Xenon Pharmaceuticals USA Inc.) is based in the Boston area. Minimum 15 minutes delayed. The trial met its primary efficacy endpoint with XEN1101 demonstrating a statistically significant and dose-dependent reduction from baseline in monthly (defined as 28 days) focal seizure frequency when compared to placebo (monotonic dose response; p<0.001). Epilepsy is a chronic neurologic disorder, the hallmark of which is recurrent, unprovoked and unpredictable seizures. On October 4, 2021, Xenon reported positive topline results from the Phase 2b X-TOLE clinical trial, which evaluated the clinical efficacy, safety, and tolerability of XEN1101 administered as adjunctive treatment in adult patients with focal epilepsy. Our novel product pipeline of neurology therapies addresses areas of high unmet medical need, with a focus on epilepsy. NASDAQ XENE (Common Stock) $38.89 1.96 Data Provided by Refinitiv. Jefferies, J.P. Morgan, SVB Securities and Stifel acted as joint book-running managers for the offering. : 598, M. K. Technology Park, Landran, Banur Highyway, SAS Nagar, Mohali,Punjab - 140307 Neurocrine Biosciences is conducting a Phase 2 clinical trial evaluating NBI-921352 in adult patients with focal onset seizures, with data expected in 2023. There have been no treatment emergent AEs of pigmentary abnormalities reported during the DBP or OLE. For poorly managed patients, physicians increasingly turn to complementary mechanisms used as adjunctive therapy to control seizures. The webcast will be broadcast live on the Investors section of the Xenon website. All other trademarks belong to their respective owner. XEN007 (active ingredient flunarizine) is a CNS-acting Cav2.1 and T-type calcium channel modulator that is being studied in treatment-resistant absence seizures and potentially other neurological. Burnaby, BC V5G 4W8, Tel: 604.484.3300 Co-founder and Senior Research Fellow Shane Kovacs Chief Operating and Financial Officer General and administrative expenses for the year ended December 31, 2021 were $22.0 million compared to $12.9 million for the same period in 2020. XENE. Cash and cash equivalents and marketable securities as of December 31, 2021 were $551.8 million, compared to $177.0 million as of December 31, 2020. Xenon Pharmaceuticals Advancing a novel product pipeline of neurology therapies View Product Pipeline About We are a clinical stage biopharmaceutical company committed to developing innovative therapeutics to improve the lives of patients with neurological disorders. Pursuant to the terms of the agreement, Xenon has the potential to receive certain clinical, regulatory, and commercial milestone payments, as well as future sales royalties. Greater Boston, primarily Boston and Cambridge, is home to almost 1,000 biotechnology companies, ranging from small start-ups to billion-dollar pharmaceutical companies. In addition, the ongoing X-TOLE open-label extension also continues to generate important long-term data for XEN1101 in FOS. Price: - On Genuine Enquiry. On December 3, 2021, Xenon presented X-TOLE clinical data at the annual meeting of the American Epilepsy Society (AES2021). Weighted-average common shares outstanding: Investor/Media Contact:Jodi RegtsXenon Pharmaceuticals Inc.Phone: 604.484.3353Email: investors@xenon-pharma.com, . Fax: 604.484.3450 This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995 and Canadian securities laws. 3650 Gilmore Way XEN402 has been formulated for extended release from a thermosensitive hydrogel and is now known as PCRX301 (previously FX301). Data Provided by Refinitiv. As of December 31, 2021 there were 51,634,752 common shares, 2,775,996 pre-funded warrants and 1,016,000 Series 1 Preferred Shares outstanding. 3650 Gilmore Way You can contact us for more details call us:+91 9310577789. XEN496XEN496, a Kv7 potassium channel opener, is a proprietary pediatric formulation of the active ingredient ezogabine being developed for the treatment of KCNQ2 developmental and epileptic encephalopathy (KCNQ2-DEE). In addition, a Phase 2 clinical trial is underway evaluating NBI-921352 in patients aged between 2 and 21 years with SCN8A developmental and epileptic encephalopathy (SCN8A-DEE). A Phase 1b proof-of-concept trial is underway evaluating the safety and tolerability of PCRX301 administered as a single-dose, popliteal fossa block in patients undergoing bunionectomy, with data now anticipated in the second quarter of this year. BURNABY, British Columbia, June 27, 2022 (GLOBE NEWSWIRE) -- Xenon Pharmaceuticals Inc. (Nasdaq:XENE), a clinical stage biopharmaceutical company, today announced the closing of its previously announced underwritten public offering of 9,098,362 common shares, which includes 1,229,508 shares sold upon the full exercise of the underwriters option to purchase additional shares, and pre-funded warrants to purchase 327,868 common shares. INDIA info@xenon-pharma.com. Xenon Pharmaceuticals Is An Ethical Pharma Company. Copyright 2001 2022 Xenon All rights reserved. The primary efficacy endpoint is the median percent change (MPC) in monthly seizure frequency from baseline through the DBP of XEN1101 compared to placebo. They are registered in the United States and used or registered in various other jurisdictions. No sales of common shares will be made in Canada. (MD of the Company) Cardiac/Diabetes; Orthopeadic; The X-TOLE open-label extension, which has been extended to three years, is expected to continue to generate important long-term data for XEN1101. It Offers High Quality Products With Attractive Packing, Reasonable Prices And Dedicated Service Focussed On Eye & ENT Care. Xenon Pharmaceuticals Inc. Individuals are diagnosed with epilepsy if they have two unprovoked seizures (or one unprovoked seizure with the likelihood of recurrent seizures) that were not caused by a known and reversible medical condition. Xenon and the Xenon logo are registered trademarks or trademarks of Xenon Pharmaceuticals Inc. in various jurisdictions. Based on the EOP2 meeting, Xenon and the FDA aligned on key elements of the Phase 3 program to support a New Drug Application (NDA) submission. Helping To Maintain Vision, Hearing Ability And Healthy . Additional primary and secondary measures included a pairwise comparison of each active dose to placebo and a responder analysis with the proportion of patients who achieved a 50% or greater reduction in monthly focal seizure frequency from baseline. As was the case in the DBP, two AEs of urinary retention occurred in the OLE possibly related to study drug; both patients continued in the study without requiring intervention. We are a clinical stage biopharmaceutical company committed to developing innovative therapeutics to improve the lives of patients with neurological disorders. The biotech's shares, in fact, jumped by as much as . These forward-looking statements are based on current assumptions that involve risks, uncertainties and other factors that may cause the actual results, events, or developments to be materially different from those expressed or implied by such forward-looking statements. The decrease was primarily attributable to a decrease in interest income and an unrealized loss on fair value of marketable securities recognized for the year ended December 31, 2021 due to fluctuations in market interest yields. Focal seizures account for approximately 60% of seizures in the U.S., which results in a total focal onset seizure patient population of approximately 1.8 million patients. Approximately 96% of patients who completed the randomized phase of the XEN1101 Phase 2b X-TOLE study rolled over into the OLE, with 231, 193 and 54 patients having now been treated in the trial for at least 6 months, 12 months, and 2 years, respectively. These multicenter, randomized, double-blind, placebo-controlled trials will evaluate the clinical efficacy and safety of XEN1101 administered as adjunctive treatment in patients with FOS. These risks and uncertainties, many of which are beyond our control, include, but are not limited to: research and clinical development plans and timelines and results of operations, including impact on our clinical trial sites, collaborators, and contractors who act for or on our behalf, may be more severe and more prolonged than currently anticipated; clinical trials may not demonstrate safety and efficacy of any of our or our collaborators product candidates; our assumptions regarding our planned expenditures and sufficiency of our cash to fund operations may be incorrect; our ongoing discovery and pre-clinical efforts may not yield additional product candidates; any of our or our collaborators product candidates may fail in development, may not receive required regulatory approvals, or may be delayed to a point where they are not commercially viable; we may not achieve additional milestones in our proprietary or partnered programs; regulatory agencies may impose additional requirements or delay the initiation of clinical trials; regulatory agencies may be delayed in reviewing, commenting on or approving any of our or our collaborators clinical development plans as a result of the COVID-19 pandemic, which could further delay development timelines; the impact of competition; the impact of expanded product development and clinical activities on operating expenses; impact of new or changing laws and regulations; the impact of the COVID-19 pandemic on our business, adverse conditions in the general domestic and global economic markets; as well as the other risks identified in our filings with the Securities and Exchange Commission and the securities commissions in British Columbia, Alberta and Ontario. Xenon Pharmaceuticals Product Pipeline Xenon is focused on advancing our ion channel neurology pipeline. More >> August 9, 2022 Vikas Puri New Delhi 110018; Home; About Us; Our Products. A focal seizure is localized within the brain and can either stay localized or spread to the entire brain, which is typically categorized as a secondary generalized seizure. These U.S. patents are expected to expire in 2040 and 2039, respectively, absent any extensions of patent term. Our Team leadership board of directors scientific advisory board Sean P. Bohen, M.D., Ph.D. President and CEO Cyrus Harmon, Ph.D. Chief Research Officer Naseem Zojwalla, M.D. Patients will undergo an 8-week baseline period to assess seizure frequency and eligibility for randomization, followed by a 12-week double blind period (DBP). Xenon continues to execute on its comprehensive strategy to protect and expand the intellectual property portfolio that covers XEN1101. Currency in USD Follow 2W 10W 9M 36.77. The treatment of an individual patient with focal seizures is currently focused on reduction of seizure frequency, with seizure freedom as the ultimate goal. 1 min read. Xenon continues to execute on its comprehensive strategy to protect and expand the intellectual property portfolio that covers XEN1101. BURNABY, British Columbia, June 27, 2022 (GLOBE NEWSWIRE) -- Xenon Pharmaceuticals Inc. (Nasdaq:XENE), a clinical stage biopharmaceutical company, today announced the closing of its previously announced underwritten public offering of 9,098,362 common shares, which includes 1,229,508 shares sold upon the full exercise of the underwriters' option to purchase additional shares, and pre-funded . 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